None of them work as quickly or as completely as the various BCR-ABL targeting drugs for CML.Just a couple of years ago, we got the same rush from the news media about immunotherapy checkpoint inhibitors. In fact, many other TKI’s have been developed and approved for cancers like lung, breast, melanoma, kidney. There were news organizations all over the place and for several years, everyone was expecting that every mutation treated by a TKI would shut down just like the BCR-ABL mutation in CML.That did not happen. It’s a remarkable story.I remember being present at ASCO, the yearly cancer conference, with attendance from all over the globe as the data were being presented on CML and this incredible breakthrough treatment.
We got him into a trial and within a month he was headed to a remission which has lasted for more than 20 years.
is a tyrosine kinase inhibitor, a TKI, which shuts down the driver mutation and results in long durable remissions and probable cures.I had a man at that time who was on and in accelerated phase going into acute leukemia. It’s now referred to as BCR-ABL, as DNA is swapped between chromosomes 9 and 22. In the old days, it was called the Philadelphia chromosome. People could live a number of years with it but every year, about a fourth of the surviving patients would develop acute leukemia in the form of blast crisis and die within a couple of months.There was a mutation driving CML.
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